Mesrine: Killer Instinct introduces us to Jacques Mesrine (Vincent Cassel), a loyal son and dedicated soldier back home and living with his parents after serving in the Algerian War. Soon he is seduced by the neon glamour of sixties Paris and the easy money it presents. Mentored by Guido (Gerald Depardieu) Mesrine turns his back on middle class law-abiding and soon moves swiftly up the criminal ladder. After pulling off an audacious heist he and his lover Jeanne (Cecile de France) flee to Canada where the opportunity of one big payout lures him out of hiding and propels his towards international notoriety.